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In mass spectrometry, inlet ionization is a soft ionization technique which involves the transfer of particles of the analyte/matrix sample from atmospheric pressure (AP) to the heated inlet tube connecting the AP region to the vacuum of the mass analyser. Initial ionization occurs as the pressure drops within the inlet tube. Inlet ionization is similar to electrospray ionization in that a reverse phase solvent system is used and the ions produced are highly charged, however a voltage or a laser is not always needed.〔 It is a highly sensitive process for small and large molecules like peptides, proteins〔Inlet Ionization: A New Highly Sensitive Approach for Liquid Chromatography/Mass Spectrometry of Small and Large Molecules Vincent S. Pagnotti, Ellen D. Inutan, Darrell D. Marshall, Charles N. McEwen, and Sarah Trimpin Analytical Chemistry 2011 83 (20), 7591-7594 DOI: 10.1021/ac201982r 〕 and lipids〔Matrix Assisted Ionization: New Aromatic and Nonaromatic Matrix Compounds Producing Multiply Charged Lipid, Peptide, and Protein Ions in the Positive and Negative Mode Observed Directly from Surfaces Jing Li, Ellen D. Inutan, Beixi Wang, Christopher B. Lietz, Daniel R. Green, Cory D. Manly, Alicia L. Richards, Darrell D. Marshall, Steven Lingenfelter, Yue Ren, Sarah Trimpin〕 that can be coupled to a liquid chromatograph. Inlet ionization techniques can be used with an Orbitrap mass analyzer, Orbitrap fourier transform mass spectrometer, linear trap quadrupole and MALDI-TOF. ==Types of inlet ionization== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Inlet ionization」の詳細全文を読む スポンサード リンク
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